« How Many People Are Uninsured? Part 2 | Main | Another Piece Of The Puzzle To Repair The Healthcare System »

Comments

Source: http://www.sciencedaily.com/releases/2007/10/071016131514.htm

Science Daily — Researchers have discovered that the structure of human bones is vastly different than previously believed -- findings which will have implications for how some debilitating bone disorders are treated.
Researchers from the University of Cambridge, the Animal Health Trust in Newmarket, and the BAM Federal Institute of Materials Research and Testing, Berlin, have discovered that the characteristic toughness and stiffness of bone is predominantly due to the presence of specialized sugars, not proteins, as had been previous believed. Their findings could have sweeping impacts on treatments for osteoporosis and other bone disorders.
Scientists have long held the view that collagen and other proteins were the key molecules responsible for stabilizing normal bone structure. That belief has been the basis for some existing medications for bone disorders and bone replacement materials. At the same time, researchers paid little attention to the roles of sugars (carbohydrates) in the complex process of bone growth.
For this research, funded by the Biotechnology and Biological Sciences Research Council (BBSRC), the UK and Berlin teams studied mineralization in horse bones using an analysis tool called nuclear magnetic resonance (NMR). They found that sugars, particularly proteoglycans (PGs) and glycosaminoglycans (GAGs), appear to play a role which is as important as proteins in controlling bone mineralization - the process by which newly-formed bone is hardened with minerals such as calcium phosphate.
Osteoporosis is a chronic and widespread disease in which mineral formation is disturbed, leading to brittle bones, pain, and increased fractures. Osteoarthritis, a hallmark of which is joint cartilage and GAG depletion, is also accompanied by abnormal bone mineralization.
Both of these diseases can be debilitating, often crippling, to older people -- a problem which will only intensify as our population ages. Among the young, especially sportsmen and women, bone and joint injuries prove the most intractable and are also the ones most likely to develop into afflictions (such as osteoarthritis) later in life.
Dr David Reid, from the Duer Group, Department of Chemistry,at the University of Cambridge, who played a significant part in the research, said, "We believe our findings will alter some fundamental preconceptions of bone biology. On a practical level they unveil novel targets for drug discovery for bone and joint diseases, new biomarkers for diagnosis, and new strategies for developing synthetic materials that could be used in orthopaedics.
"They may also strengthen the rationale for the current popularity of over-the-counter joint and bone pain remedies such as glucosamine and chondroitin, which are based on GAG sugar molecules."
Note: This story has been adapted from material provided by University of Cambridge.

Fausto Intilla
http://www.oloscience.com

Note that both AARP and The American Cancer Society are devoting their annual advertising budgets to reforming healthcare due to the fact that preventive medicine is leading to a leveling off of the drop off in both chronic disease and cancer rates. It's a subject addressed in a video running on YouTube. http://www.youtube.com/watch?v=zHk3pdfzdvI

Verify your Comment

Previewing your Comment

This is only a preview. Your comment has not yet been posted.

Working...
Your comment could not be posted. Error type:
Your comment has been saved. Comments are moderated and will not appear until approved by the author. Post another comment

The letters and numbers you entered did not match the image. Please try again.

As a final step before posting your comment, enter the letters and numbers you see in the image below. This prevents automated programs from posting comments.

Having trouble reading this image? View an alternate.

Working...

Post a comment

Comments are moderated, and will not appear until the author has approved them.

Your Information

(Name and email address are required. Email address will not be displayed with the comment.)

Http://stan.feld.com
My Photo

Subscribe in
NewsGator Online

Subscribe in
Bloglines

Enter your email address:

Delivered by FeedBurner